Stephen Hales, D.D., F.R.S

01 Hales

The thrifty phenotype hypothesis proposes that the epidemiological associations between poor fetal and infant growth and the subsequent development of type 2 diabetes and the metabolic syndrome result from the effects of poor nutrition in early life, which produces permanent changes in glucose-insulin metabolism. These changes include reduced capacity for insulin secretion and insulin resistanc...

Stephen Hales: the contributions of an Enlightenment physiologist to the study of the kidney in health and disease.

Stephen Hales (1677-1761) was an English clergyman who made major contributions to a wide range of scientific topics such as botany, chemistry, pneumatics, and physiology. Early in his career he developed a keen interest in medicine through his association with his younger physician friend at Cambridge, William Stukeley (1687-1765), with whom he dissected animals and attended experiments in the...

Elected FRS 1976

A density Hales-Jewett theorem for matroids

We show that if α is a positive real number, n and ` are integers exceeding 1, and q is a prime power, then every simple matroid M of sufficiently large rank, with no U2,`-minor, no rank-n projective geometry minor over a larger field than GF(q), and at least αq elements, has a rank-n affine geometry restriction over GF(q). This result can be viewed as an analogue of the multidimensional densit...

Stephen H Bryant and Stephen F Altschul

The past two years have seen the rapid development of new recognition methods for protein structure prediction. These algorithms ’thread’ the sequence of one protein through the known structure of another, looking for an alignment that corresponds to an energetically favorable model structure. Because they are based on energy calculation, rather than evolutionary distance, these methods extend ...